KMID : 1195620220150010091
|
|
Clinical and Experimental Otorhinolaryngology 2022 Volume.15 No. 1 p.91 ~ p.99
|
|
Effectiveness of Intratympanic Dexamethasone Injection for Tinnitus Treatment: A Systematic Review and Meta-Analysis
|
|
Chung Ju-Yong
Lee Doh-Young Kim Jong-Seung Kim Young-Ho
|
|
Abstract
|
|
|
Objectives: Intratympanic dexamethasone injection (ITDI) has been introduced as a treatment option for subjective tinnitus. However, the effects of ITDI on patients with tinnitus remain unclear. In the present systematic review and meta-analysis, we evaluated the effectiveness of ITDI for tinnitus treatment.
Methods: We searched Medline, the Cochrane Central Register of Controlled Trials, and Embase. Four double-blind randomized controlled trials that tested the efficacy of ITDI compared with a placebo were deemed eligible for a quantitative meta-analysis, while four prospective studies and seven retrospective studies reporting the effectiveness of ITDI on tinnitus treatment were included in a qualitative synthesis.
Results: In the four studies included in the quantitative meta-analysis, ITDI did not show evidence of tinnitus improvement compared with placebo (odds ratio [OR], 1.38; 95% confidence interval, 0.53?3.61). In the 11 studies included in the qualitative synthesis, seven retrospective studies without controls reported rates of tinnitus improvement after ITDI ranging from 35.9% to 91.3%. In the four prospective studies with controls, ITDI seemed to be effective when combined with other drugs for tinnitus treatment.
Conclusion: ITDI alone did not show a significant effect for treating tinnitus compared with placebo. However, the potential of combination treatment of ITDI with other drugs for tinnitus therapy should be further studied in more systematic research.
|
|
KEYWORD
|
|
Tinnitus, Injection, Intratympanic, Steroids, Dexamethasone
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|